김정헌
· huney1926@kogene.co.kr
· huney1926@skku.edu
- 학력
2002 ~ 2011 서울대학교 의과대학 미생물학교실 (석·박사)
1995 ~ 2002 서울대학교 응용생물화학부 (학사)
- 약력/경력
(현) 2020 ~ 현재 코젠바이오텍 연구소장
(전) 2019 ~ 2020 서울대학교 의학연구원 감염병연구소 연구 교수
(전) 2017 ~ 2019 서울대학교 의학연구원 감염병연구소 연구 부교수
(전) 2012 ~ 2017 Louisiana State University, Health Science Center, U.S.A. 박사후 연구원 (Post-Doctoral Fellow)
- 관심분야
미생물학, 바이러스학, 유전자 진단 및 분석 기술
- 연구키워드
감염, 미생물, 바이러스, 진단, 분자진단
- 논문/연구성과
· Sang Hyuk Park, Hyun-Ki Kim, Hang Kang, Jung Heon Kim, Jaeseung Lee, Ji-Hun Lim, Seon-Ho Lee, Joseph Jeong. Incidence Evaluation of SARS-CoV-2 Variants in the Ulsan Area, Korea, Using PowerChek SARS-CoV-2 S-gene Mutation Detection Kit: A Pilot Study. Ann Lab Med. 2022 May 1;42(3):363-366.
· Hailian Quan, Jiyeon Kim, Yi Rang Na, Jung Heon Kim, Byoung-Jun Kim, Bum-Joon Kim, Jung Joo Hong, Eung Soo Hwang, Seung Hyeok Seok. Human Cytomegalovirus-Induced Interleukin-10 Production Promotes the Proliferation of Mycobacterium massiliense in Macrophages. Front Immunol. 2020 Sep 10;11:518605
· Heather L. Fulkerson, Liudmila S. Chesnokova, Jung Heon Kim, Jamil Mahmud, Laura E. Frazier, Gary C. Chan, and Andrew D. Yurochko. HCMV-induced signaling through gB–EGFR engagement is required for viral trafficking and nuclear translocation in primary human monocytes. P.N.A.S August 11, 2020 117 (32) 19507-19516
· Eun-Ha Hwang, Green Kim, Hanseul Oh, You Jung An, Jiyeon Kim, Jung Heon Kim, Eung-Soo Hwang, Jong-Hwan Park, JungJoo Hong, Bon-Sang Koo. Molecular and Evolutionary Analysis of Dengue Virus Serotype 2 Isolated in Korean Travelers. Archives of Virology, 2020.15.14., 165, pages1739–1748
· Soo-Yeon Choi, Jung Heon Kim, Jiyeon Kim, and Eung-Soo Hwang. World Outbreak Trend of Infectious Diseases with Surveillance. J Bacteriol Virol. Vol 49. No 3. September 2019; 49(3): 141-151
· Jung Heon Kim, Jiyeon Kim, Bon-Sang Koo, Hanseul Oh, Jung-Joo Hong, and Eung-Soo Hwang. Rapid Whole-genome Sequencing of Zika Viruses using Direct RNA Sequencing. J Bacteriol Virol. Vol 49. No 3. September 2019; 49(3): 115-123
· Lindsey B. Crawford, Jung Heon Kim, Donna Collins-McMillen, Byeong-Jae Lee, Igor Landais, Christine Held, Jay A. Nelson, Andrew D. Yurochko, and Patrizia Caposio. Human Cytomegalovirus Encodes a Novel FLT3 Receptor Ligand Necessary for Hematopoietic Cell Differentiation and Viral Reactivation. mBio. 2018 Mar-Apr; 9(2): e00682-18.
· Jung Heon Kim, Wonjun Bae, Jiyeon Kim, and Eung Soo Hwang. An Urgent Need for Global Preparedness against the Reemergence of “Forgotten” Infectious Diseases in Korea. J Korean Med Sci. 2018 Apr 23; 33(17): e125.
· Jung Heon Kim, Jiyeon Kim, Jin Roh, Chan-Sik Park, Ju‐Young Seoh, and Eung Soo Hwang. Reactive oxygen species‐induced parthanatos of immunocytes by human cytomegalovirus‐associated substance. Microbiol Immunol. 2018 Apr; 62(4): 229–242.
· Wonjun Bae, Jung Heon Kim, Jiyeon Kim, Jungyun Lee, Eung Soo Hwang. Changes of Epidemiological Characteristics of Japanese Encephalitis Viral Infection and Birds as a Potential Viral Transmitter in Korea. J Korean Med Sci. 2018 Feb 26; 33(9): e70.
· Donna Collins-McMillen, Emily Stevenson, Jung Heon Kim, Stephen Cieply, Maciej Nogalski, Gary Chan, Robert Frost III, Caroline Spohn, and Andrew D. Yurochko. HCMV utilizes a non-traditional STAT1 activation cascade via signaling through EGFR and integrins to efficiently promote the motility, differentiation, and polarization of infected monocytes. J Virol. 2017 Dec 15; 91(24): e00622-17.
· Jung Heon Kim, Donna Collins-McMillen, Jason C. Buehler, Felicia D. Goodrum, and Andrew D. Yurochko. HCMV requires EGFR and PI(3)K signaling to enter and establish latency in CD34+ progenitor cells. J Virol, (2017), March 1; 91(5): e01206-16
· Jung Heon Kim, Donna Collins-McMillen, Patrizia Caposio and Andrew D. Yurochko. Viral binding induced signaling drives a unique and extended intracellular trafficking pattern during infection of primary monocytes. P.N.A.S (2016), Aug 2; 113(31): 8819-8824
· Donna Collins-McMillen, Jung Heon Kim, Maciej T. Nogalski, Emily V. Stevenson, Gary C.T. Chan, Joshua Caskey, Stephen J. Cieply and Andrew D. Yurochko, HCMV Promotes Survival of Infected Monocytes via a Distinct Temporal Regulation of Cellular Bcl-2 Family Proteins. J Virol. (2015) Dec 16;90(5):2356-71
· Jiyeon Kim, Jung Heon Kim, and Eung Soo Hwang, Induction of PERV antigen in porcine peripheral blood mononuclear cells by human herpesvirus, Xenotransplantation. (2015) Mar-Apr;22(2):144-50.
· Emily V. Stevenson, Donna Collins-McMillen, Jung Heon Kim, Stephen J. Cieply, Gretchen L. Bentz, and Andrew D. Yurochko, HCMV Reprogramming of Infected Monocyte Survival and Differentiation: A Goldilocks Phenomenon, Viruses (2014), 6, 782-807.
· Yejin Kwon, Jiyeon Kim, Jung Heon Kim, and Eung Soo Hwang, Cytoplasmic Translocation of p53 by Human Cytomegalovirus Infection, J Bacteriol Virol. 2013 Dec;43(4):297-306.
· Yejin Kwon, Mi‐Na Kim, Eun Young Choi, Jung Heon Kim, Eung‐Soo Hwang, Chang‐Yong Cha, Inhibition of p53 transcriptional activity by human cytomegalovirus UL44, Microbiol Immunol, 2012;56: 324–331
· Dokyung Yoon, Daekwang Woo, Jung Heon Kim, Moon Ki Kim, Taesung Kim, Eung-Soo Hwang, Seunghyun Baik. Agglomeration, sedimentation, and cellular toxicity of alumina nanoparticles in cell culture medium, Journal of Nanoparticle Research volume 13, pages2543–2551 (2011)
· Jung Heon Kim, Eun-Suk Jung, Yejin Kwon, E-Y Choi, H Jeong, S Kim, Chung-Gyu Park, Sang Joon Kim, Eung-Soo Hwang, Infection of porcine cells with human herpesviruses, Transplant Proc. Jul-Aug 2010;42(6):2134-7.
· Jung Heon Kim, Eun-Suk Jung, Chung-Gyu Park, Sang Joon Kim, Eung Soo Hwang, No Evidence of the Productive Replication of Porcine Endogenous Retrovirus (PERV) from SNU Miniature Pigs in Human Cell Line, Infect Chemother. 2010 Jun;42(3):175-180
· Jung Heon Kim, Eun-Suk Jung, Eung-Soo Hwang, Detection of Human Cytomegalovirus (HCMV) and Porcine Endogenous Retrovirus (PERV) with One Step Extraction Method, Infect Chemother. 2010 Feb;42(1):12-16.
· Chengfan Cao, Jung Heon Kim, Ye-Jin Kwon, Young-Jin Kim, Eung-Soo Hwang, Seunghyun Baik, An immunoassay using biotinylated single-walled carbon nanotubes as Raman biomarkers, Analyst. 2009 Jul;134(7):1294-6
· Jung Heon Kim, Eun young Choi, Eun-Suk Jung, Yejin Kwon, Dong Suk Lee, Do Yeong Hwang, Eung Soo Hwang, Characterization of Clones of Human Cell Line Infected with Porcine Endogenous Retrovirus (PERV) from Porcine Cell Line, PK-15, Infect Chemother. 2009 Jan-Feb;41(1):1-8.
· Chengfan Cao, Jung Heon Kim, Dokyung Yoon, Eung-Soo, Hwang, Young-Jin Kim, Seunghyun Baik, Optical detection of DNA hybridization using absorption spectra of single-walled carbon nanotubes, Materials Chemistry and Physics, Volume 112, Issue 3, 20 December 2008, Pages 738-741
· John J. Harvey, S. Paul Lee, Edward K. Chan, Jung Heon Kim, Eung-Soo Hwang, Chang-Yong Cha, Jay R. Knutson, Myun K. Han, Characterization and applications of CataCleave probe in real-time detection assays, Analytical Biochemistry Volume 333, Issue 2, 15 October 2004, Pages 246-255
· Ye Jin Kwon, Dae-Joong Kim, Jung Heon Kim, Chung-Gyu Park, Chang-Yong Cha, Eung-Soo Hwang, Human cytomegalovirus (HCMV) infection in osteosarcoma cell line suppresses GM-CSF production by induction of TGF-beta, Microbiol Immunol, 2004;48(3):195-9
· Jinhee Kim, Ye Jin Kwon, Eun-Suk Park, Bohyun Sung, Jung Heon Kim, Chung-Gyu Park, Eung-Soo Hwang, Chang-Yong Cha, Human cytomegalovirus (HCMV) IE1 plays role in resistance to apoptosis with etoposide in cancer cell line by Cdk2 accumulation, Microbiol Immunol, 2003;47(12):959-67.
- 특허/지적재산권
· 마이코플라스마 갈리셉티쿰의 야외주와 백신주를 동시에 구별하여 검출하기 위한 조성물 및 이를 이용한 검출방법.
· 사람 엔테로바이러스, 엔테로바이러스 71 또는 이들을 동시에 검출할 수 있는 엔테로바이러스 검출 방법.
· 인플루엔자 A형 및 B형 바이러스와 제2형 중증급성호흡기증후군 코로나바이러스를 구별하여 동시에 검출하기 위한 조성물 및 이를 이용한 검출 방법.
· 실시간 중합효소연쇄반응을 이용한 수두바이러스 검출 및 정량 방법.
· 말라리아 5종 검출용 프라이머 세트
· 결핵균 및 베이징 계통 결핵균의 감별을 위한 조성물 및 이를 이용한 결핵균 검출 방법.
· 결핵균의 유전자형 분류를 위한 MIRU-VNTR 조성물 및 이를 이용한결핵균 유전자형 분류방법
· The simultaneous analysis of whole genome sequencing of four serum types (1, 2, 3 and 4) of dengue viruses.
· Primer Set for Detection of Porcine Endogenous Retrovirus
- 수상
· The 27th Federation Meeting of Korean Basic Medical Scientists Poster Award
· The Korea Society of Virology Poster Award
· Selected for “한국을 빛내는 사람들” at Biological Research Information Center (BRIC)
· Graduate Research Day Postdoc Poster Award
· Malcolm Feist Cardiovascular Research Fellowship
- 자문위원
· 감염질환진단 신속자동화 플랫폼 신뢰성 평가 방법(분자진단). 전문가 자문위원. 주최: 한국기계전기전자시험연구원(KTC).
· 감염병 위기대응 핵심기술 도출 및 정부 R&D 지원전략 수립. 정책연구 자문위원. 주최: 한국과학기술기획평가원(KISTEP).
· 코로나19 관련 동물분야 R&D 협의회. 자문위원. 주최: 농림축산검역본부.
· 병원체자원 수집 강화 및 활용 촉진을 위한 간담회. 자문위원. 주최: 질병관리청 병원체자원관리과.
- 학술활동(발표 활동)
· INU 글로벌 바이오 융합 포럼
· Annual International Herpesvirus Workshop
· Federation Meeting of Korean Basic Medical Scientists
· The Korea Society of Virology
· International Meeting of the Federation of Korean Microbiological Societies
· Global Center for Infectious Disease
· Gulf Coast Vascular Research Consortium
· Annual Malcolm Feist Lecture on Translational Research in Cardiovascular Diseases
· South Central Branch of ASM